Prevalence of Rate-Dependent Behaviors in Cardiac Muscle
نویسندگان
چکیده
We explore the rate-dependent dynamic response of periodically paced bullfrog (Rana catesbeiana) cardiac muscle. Alternans (2:2 behavior) occur in 35% of animals and 2:1 $ 1:1 bistability in 74% of animals. In addition, we observe 2:2 $ 2:1 bistablility. We discuss the implications of these results for two map-based models of cardiac dynamics. The high prevalence of bistability suggests that this dynamical behavior must be accounted for in the design of closed-loop feedback protocols to stabilize cardiac dynamics. [S0031-9007(99)08837-7]
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